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The most common reason for reverting is slower-than-expected progress, suggesting that the glucagon threshold concern is not merely theoretical

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10.1016/j.drugalcdep.2024.112424

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Son YJ, Phue JN, Trinh LB, Lee SJ, Shiloach J

This pathway is antagonized by several factors, including Phosphatase and Tensin homolog (PTEN) and Protein tyrosine phosphatase 1B (PTP1B)