Note that with this method of delivery absorption occurs predominantly in the stomach to achieve therapeutic plasma levels, and overcomes otherwise insurmountable challenges of peptide absorption related to solubility, molecular size, and enzymatic degradation in the protease-rich environment of the small intestine (Buckley et al, 2018)
The FDA based its decision on results from the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial
So with patients 65 and older, I am more cautious with the medication
Getting the dilution right matters because incorrect reconstitution leads to inaccurate dosing, which undermines the entire dose escalation schedule
If your stomach is sensitive, start with acacia fiber or PHGG and work your way up slowly
Coffee also increases stomach acid production