Safety data for the metforminonly population from SUSTAIN FORTE were also not available and, therefore, no formal adjusted indirect comparisons were conducted
Even metformin, the most prescribed drug for T2D, acts at least partly via the gut to lower blood glucose via gutbrainliver signaling mechanisms that lower hepatic glucose production or via alterations in gut microbiota and bile acid signaling 6,7,8
Off-label or unlicensed use of medicines: prescribers' responsibilities
Underdosing, which may affect treatment response
That dual mechanism is why the weight loss numbers from trials are so dramatically higher than anything else in the pipeline
11 Importantly, this study showed that treatment with tirzepatide resulted in a 27% odds reduction in developing any DR or DME in patients who had no DR/DME at baseline