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IRP2 expression is significantly upregulated in the midbrain substantia nigra of PD mice, increasing TFR1, FTH, and p53 levels, while decreasing SLC7A11 and GPX4 levels, leading to ferroptosis and disruption of the amino acid antioxidant system in dopaminergic neurons

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In the first year or two after bariatric surgery, patients typically lose weight through consistent diet, exercise and behavior changes, said Buie, who also sees patients at UChicago Medicine locations in Orland Park and Tinley Park

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