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Common risk factors for NAION include: Diabetes High blood pressure High cholesterol Sleep apnea Small or crowded optic nerves Smoking Cardiovascular disease Older age These risk factors are important because many patients who take GLP-1 medications may already have diabetes, obesity, sleep apnea, or vascular risk factors that can also increase NAION risk

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In preclinical research models, the timeline for metabolic response will depend on species, dose, and the specific endpoints being measured

[31] [32] Cortisol has several essential functions in the body

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Alpha lipoic acid protects heart against myocardial ischemiareperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation