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Janse and Blandine Franke-Fayard for helpful discussions at the initiation of the project and for performing a transfection with the pbgst-ko 1B plasmid at their laboratory

For skin specifically, this matters because the accumulation of senescent fibroblasts in aging dermis is one of the primary drivers of collagen loss

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What causes it and how to help quiet it, according to experts - CBS News, accessed April 22, 2025, Understanding Food Noise and How GLP-1 Medications Help Silence It - Flow Wellness, accessed April 22, 2025, GLP-1 Receptor Agonists and Related Mental Health Issues

In the following sections, we cover a few urolithin A alternatives

Ongoing research is examining the effects of exercise, including resistance training in combination with GLP-1 RA therapy (ClinicalTrials.gov: NCT05786521, NCT04122716)