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To achieve a plasma level of 0.7mM (less than the 1mM used int he paper), you have to give a rat 150mg/kg/day IV, which is the equivalent of a 1451mg IV SAMe daily dose to a 60kg human, but since the oral absorption is around 5%, that's the equivalent of more than a 29,000mg daily oral dose

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Additionally, researchers found that GLP-1R neurons in the area of the Interestingly, activation of the area postrema GLP-1R neurons causes nausea, but activation of nucleus tractus solitarius GLP-1R neurons causes satiety without nausea, Alhadeff explained