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Dinleyici Ec et al
When histamine levels exceed the body's degradative capacity, individuals may experience a wide range of symptoms including headaches, flushing, nasal congestion, gastrointestinal disturbances (such as bloating, diarrhoea, or abdominal pain), skin reactions (urticaria, itching), palpitations, dizziness, and fatigue
The safety and efficacy of citrus aurantium (bitter orange) extracts and p-synephrine: a systematic review and meta-analysis
10.1007/s00284-022-02825-5 103
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While too many patients discontinue, even more patients won't even start if they know they have to stay on drug forever
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