Given the lipid-rich composition of myelin, such metabolic perturbations precipitate myelin deterioration and demyelination, leading to a decrease in nerve conduction velocity (Johnson and Stolzing, 2019
Tucked Up Tummy After having kids, a botched tummy tuck left Maranda with a life-threatening infection that resulted in a horrible scar across her stomach
Lifespan extension in animal studies Rodent studies (most extensive data): Mice lifespan increased 20-42% with Epithalon Rats showed 12-25% lifespan extension Both maximum lifespan and median lifespan increased Healthspan (healthy years) improved even more Similar to effects seen with caloric restriction but without dietary limitation Study examples: Mechanisms of lifespan extension: Telomere preservation preventing cellular senescence Reduced oxidative damage to tissues Improved immune function preventing infections Better hormone regulation (pineal, reproductive) Reduced age-related diseases (cancer, cardiovascular) Human lifespan effects (theoretical): No completed human lifespan studies (require decades) If similar extension: 20% of 80-year lifespan = 16 additional years More realistically: Healthspan improvement more achievable than lifespan Quality of life in later years potentially enhanced Similar goals as other longevity interventions Limitations of animal data: Rodents humans (metabolism, telomere biology differ) Controlled lab conditions vs real-world human life Optimal dosing in humans unknown Long-term safety in humans not established Need rigorous human trials for validation Compare to other longevity approaches like growth hormone peptides at SeekPeptides
Involvement of cytosolic ascorbate peroxidase and Cu/Zn-superoxide dismutase for improved tolerance against drought stress
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Neuroprotective role of -lipoic acid in iron-overload-mediated toxicity and inflammation in in vitro and in vivo models
