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178 Compared with traditional single-target agents, SIRT1 activators simultaneously modulate several critical pathways, including metabolism, immune responses, and oxidative balance, offering a network reprogramming therapeutic advantage, particularly in the early stages of the disease when multiple processes are synergistically dysregulated

4 , e520e521 (2023)

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The current GHK-Cu FDA approval status is mainly influenced by high drug development costs, limited clinical data, formulation stability challenges, and its established role as a GHK-Cu cosmetic ingredient

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