"We were quite surprised," says Richard Doty, one of the study's authors and director of the Smell and Taste Center at University of Pennsylvania Medical Center
These recommendations were motivated by the results of a recent cardiovascular outcomes trial (SELECT study), performed in obese subjects without diabetes, which reported a 20% reduction in the composite endpoint of cardiovascular death, non-fatal myocardial infraction and non-fatal stroke
Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 randomized clinical trial
The combination of these modalities creates a synergistic effect, with HIFU providing deep structural support while other treatments address superficial concerns and underlying nutritionparticularly valuable during the rapid changes associated with GLP-1 weight loss
GLP-1, GIP, exendin-4 and liraglutide had suppressive effects on oxLDL-induced foam cell formation, which is linked with the suppression of infiltrated macrophage foam cells in atherosclerotic plaques, resulting in repressed atherosclerotic plaque formation
GLP-1 receptor activation handles appetite suppression and appetite control