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This counteracting effect of L-carnitine was dose-dependent and statistically significant at least at 4 h of exposure (Figure 6)

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When taken orally, they face two major obstacles: Stomach acid: Hydrochloric acid (pH 1.5-3.5) denatures peptide bonds, breaking the molecule into inactive fragments before it can be absorbed Digestive enzymes: Pepsin, trypsin, and chymotrypsin in the stomach and small intestine specifically target peptide bonds for cleavage