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Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy

In accordance with this, the steady-state concentration of O 2 in the mitochondrial matrix is estimated to be five to ten times higher than that in the cytosol [56]

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Sepesi B, Cuentas EP, Canales JR, Behrens C, Correa AM, Vaporciyan A, Weissferdt A, Kalhor N, Moran C, Swisher SG , Wistuba I

It was originally isolated from human plasma in 1973 and is one of the most extensively studied copper peptides in published research literature