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GLP-1R is expressed in the AP and nucleus of the solitary tract (NTS) located in the hindbrain, and c-Fos expression after GLP-1RA injection was apparent in hindbrain GLP-1R cells, with further studies demonstrating these cells role in mediating GLP-1RA actions [59,96,102,103]

The approval of oral semaglutide expanded the range of medically supported weight loss therapies by introducing a non-injectable GLP-1 option

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In the context of precision medicine, developing optimized GLP-1RAs treatment plans based on individual cancer risk profiles while balancing diabetes management remains an urgent clinical challenge