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Hemoglobin A1c reductionsthe standard measure of long-term glucose controlbecome clinically significant after 12 weeks of therapy, with continued improvement through 24 weeks

Can Pregnant or breastfeeding individuals take semaglutide

Interestingly, exenatide in the LS does not impair anxiety-like behaviors or operant responding, which are key functions for cells within this region that indicate a fine tuning of GLP-1R action in this region

No hepatic safety signal has been identified, a finding of particular importance given the hepatotoxicity that led to the discontinuation of competing oral GLP-1 programs

But on hard outcomes VO2max, time to exhaustion, strength the evidence is inconsistent and the effect sizes are small

Food Chem 105, 727735