No, not typically
doi:10.1016/s0378-8741(01)00299-9
Choice of vial size is usually a function of dose range and use frequency, not technique
Non-selective c-Met inhibitors include crizotinib (PF-02341066), foretinib (XL-880), cabozantinib (XL-184), glesatinib (MGCD265), BMS-777607, and MK2461, which in addition to c-Met, can inhibit other tyrosine kinases, such as ALK, RON, VEGFR2, KIT, TIE2, PDGFR, VEGFR1, VEGFR3, RET, and FLT-3 [163,164,165], through binding to the ATP binding site on tyrosine kinases
These studies are mechanistically aligned with the VEGFR2/eNOS in vitro findings but rely on the same originating laboratory and rodent model system, and independent replication outside that network is sparse
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