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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

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Faraday Trans

Soluble dipeptidyl peptidase-4 induces fibroblast activation through proteinase-activated receptor-2

Mechanistic evaluation may include observation of compound interaction with signaling cascades involved in redox homeostasis, enzymatic activity, and molecular transport processes