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Since host and viral targets of ubiquitination and ISGylation are often directed to degradation, components of the proteasome, proteases, protein folding factors, and chaperones are 1.51.8-fold upregulated

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679 Tert-butylhydroquinone (TBHQ), as an Nrf2 activator, has been shown to activate Nrf2-related pathways in a TBI mouse model by combining vanillin acetate and TBHQ, reducing oxidative stress and protecting gray matter in the mouse brain