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For protocols where precise, reproducible dosing matters, and that should be all protocols, site rotation is essential

doi: 10.1210/jc.2004-1667 83 ChangFCOppMR

Changes after gastrointestinal surgery and bariatric surgery

Use of SGLT-2 inhibitors has been associated with a ~2-fold increased risk for limb amputation when compared with the use of sulfonylureas, metformin, and thiazolidinediones (Chang et al, 2018)

Peptide transformation under light exposure can convert active compounds to inactive or potentially problematic variants

they work opposite of each other so that blood sugar decreases during and right after meals (thanks to insulin), and levels increase between meals, giving the body steady energy levels (due to glucagon)