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The first few weeks are when nausea, fullness, and bowel changes show up

Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro

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These studies suggest that deficiencies in GH and IGF-I contribute to a functional decline in senescent rats, whereas augmentation of GH or IGF-I improves cognitive function, increases glucose utilization throughout the brain, increases cortical vascularity, and ameliorates age-related decline in hippocampal neurogenesis

Sleep is another critical factor, as the majority of tissue repair occurs during deep sleep cycles