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When considering any supplementation, safety is paramount

doi: 10.3390/biom12030422 159 PazekAKouckMDukovM

Liver support The liver is where most of your glutathione gets made, and it's also glutathione's biggest customer

Cardiovascular disease When combined with folate and B6, vitamin B12 can reduce homocysteine levels, which may offer benefit for cardiovascular disorders, although results from studies are mixed

Support MTHFR, MAOA, and GSR gene function for healthy homocysteine, neurotransmitter, antioxidant levels, and healthy methylation pathways with Riboflavin

Other common reasons are a local injection-site reaction, your body adjusting to corrected levels, and an underlying deficiency that was more severe than expected