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It has been demonstrated that plum and its polyphenolic chemicals directly decrease osteoblastogenesis by downregulating NFATc1 and inflammatory mediators, which lowers osteoblast activity, and limit bone resorption by downregulating RANKL (131)

Wim T Kok, Panagiotis Spyropoulous Recent developments in affinity chromatography, Page no.5, Literature Thesis University of Amsterdam, Netherland

Front Endocrinol (2022) 13:930756