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301 In addition, arginase 1 (Arg1) administration to activated T cells leading to arginine starvation can block T cell glycolysis

Patients with Renal Insufficiency For patients with mild renal insufficiency (creatinine clearance [CrCl] greater than or equal to 50 mL/min, approximately corresponding to serum creatinine levels of less than or equal to 1.7 mg/dL in men and less than or equal to 1.5 mg/dL in women), no dosage adjustment for Januvia is required

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That means it reflects patterns seen in groups of patients, not controlled experimental data

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