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Mecobalamin plays an important role in transmethylation as a coenzyme in the synthesis of methionine from homocysteine

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Figure 3 4 Cirrhosis-related non-cholestatic pruritus 4.1 Prevalence and mechanisms Pruritus linked to liver ailments is particularly pronounced in chronic cholestatic liver conditions like primary biliary cholangitis and primary sclerosing cholangitis