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Semaglutide activates only the glucagon-like peptide-1 receptor, while tirzepatide activates both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide receptor

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Maintain adequate hydration with 6-8 glasses of fluid daily, eat regular small meals to prevent low blood sugar, rise gradually from sitting or lying positions, and have your GP review blood pressure and diabetes medications for potential dose adjustments

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Continuous use may reduce effectiveness through receptor downregulation