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Metabolic phenotyping For the glucose tolerance tests, mice were fasted for 2 h (beginning at ZT0) and then administered glucose via oral gavage (2.5 g kg 1 body weight)

Impaired fusion leads to increased mutation rates and genome loss, resulting in deficiencies in oxidative phosphorylation (OXPHOS) and significantly elevated reactive ROS (52), causing insufficient energy uptake and death of dopaminergic neurons

Pacing/energy management Several guidelines have been established to guide the management of ME/CFS

The evidence deserves careful reading

While this study possesses several strengthsincluding its prospective design, strict inclusion criteria, and well-matched control groupit is also subject to certain limitations that should be considered when interpreting the results

These are typically temporary and often dose-dependent, meaning they can improve over time or with a dosage adjustment