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[34] [35] In addition, unlike the case of peripheral administration, intranasal oxytocin has a central duration of at least 2.25 hours and as long as 4 hours

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Beside a structural role in anchoring DRD2 to actin cytoskeleton and regulating receptor localization and stability, FLNA plays an additional functional role as scaffold for signaling molecules involved in DRD2 signal transduction

However, critical evaluation requires acknowledging limitations: many studies lack the sample sizes and rigorous controls standard for Western regulatory purposes, independent replication has been limited, and long-term safety data in large human cohorts is lacking