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The picture is mixed and no large trial has been done, so it is promising rather than proven

The safety of NAD+ injection has not been evaluated in women who are breastfeeding or children

No randomised controlled trial data exists yet these are hypothesis-generating, not confirmatory

It remains to be investigated whether the impact of chronic, non-responsive stimulation paradigms are as effective as the responsive cerebellar cortical or cerebellar nuclei stimulation [105, 109]

And if you're over 50, your ability to extract B12 from food naturally declines

This is a prescription drug for men or post-menopausal women