We identified 135 differentially expressed genes that overlap with AD GWAS hits, which clustered into five distinct groups based on cell type specific responses ( Fig
In addition, stem cell marker expression was remarkably reduced in SDSCs from old donors (Supplementary Fig
Importantly, GLP-1 receptor activation has also been shown to reduce amyloid- accumulation in experimental models, linking metabolic signaling directly to canonical Alzheimers pathology [14]
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