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reported a similar phenomenon in mice in which total maternal sleep deprivation led to oocyte OS, with an increase in the ROS concentration in mouse germinal vesicle (GV) and middle-intermediate II (MII) oocytes, which resulted in an increase in the number of mtDNA copies in GV-stage oocytes and a decrease in the number of mtDNA copies in MII oocytes due to a compensatory mechanism [49]

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Refrigerators are dark most of the time, but if you open the door frequently, the internal light can expose the vial to repeated low-level light

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