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Acknowledgements We gratefully acknowledge the patients and their families for participation in this study

We are ready to move on to antioxidants, which as their name indicates, combat free radicals, ROS, and oxidative stress

Notably, methotrexate is preferred for use in patients

The catalytic glutamate residue E 115 accepts a proton from the -glutamyl group of the substrate, initiating a nucleophilic attack by the amine on the amide carbon atom

89 In a parallel manner, ZIP14 moves to the mouse hepatocytes sinusoidal membrane during sharp inflammatory events

Glutathione is involved in detoxification of hydrogen peroxide through glutathione oxidase