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Pickart et al

Ignoring Individual Response Signals The Problem: Rigidly adhering to a protocol despite clear signs it's not optimal for your body

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More serious but rare adverse events include pancreatitis (0.2% incidence), gallbladder disease requiring surgical intervention, and medullary thyroid carcinoma risk in genetically predisposed individuals (contraindicated in patients with personal or family history of MTC or MEN2 syndrome)