phentermine vs retatrutide Semaglutide vs Tirzepatide vs — what's the difference? Not all weight loss medications are the same: Phentermine → appetite suppressant/stimulant, usually short-term Semaglutide → GLP-1 medication Tirzepatide → GIP + Updated Meta-Analysis of Obesity Medications

Retatrutide dosage starts at a 1 mg and is administered subcutaneously once weekly

GLP-1 weight loss injections, such as Semaglutide and Tirzepatide, mimic this hormones effects, helping to control hunger and stabilize blood sugar levels

While use of the GLP-1 medications has skyrocketed, evidence on their long-term impact is still being assessed

In the SURMOUNT-5 head-to-head trial ( N Engl J Med , May 2025), tirzepatide produced 20.2% average weight loss compared to 13.7% with semaglutide over 72 weeks a 47% greater relative reduction

Our experience serving more than 1.7M subscribers 1 , combined with our infrastructure, gives us confidence that this is the best time to begin offering access to GLP-1s

Understanding which peptides complement Retatrutide, and which create redundant or conflicting effects, helps researchers design protocols that maximize benefit while minimizing unnecessary complexity