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This wide safety margin means overdose from prescribed therapy is exceptionally uncommon when patients follow dosing schedules and communicate with their healthcare provider

These results showed that TG-induced ER stress triggered nuclear translation of NF-B, contributing to pro-inflammatory cytokine transcription and subsequently promoting an ECM catabolic process

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Application Considerations in Research: Start with a low concentration and frequency

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Its important to keep in mind though, that berberine is not safe during pregnancy