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Persistent irritation can actually reduce absorption because inflamed tissue does not absorb as efficiently as healthy tissue

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One review showed that people lost about 4 lbs of body weight when taking berberine regularly (500 mg daily)

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J Neuroinflammation 16(1):242 [DOI] [PMC free article] [PubMed] [Google Scholar] Sheahan KH, Wahlberg EA, Gilbert MP (2020) An overview of GLP-1 agonists and recent cardiovascular outcomes trials