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Baricitinib: the first Jak inhibitor approved in Europe for the treatment of moderate to severe atopic dermatitis in adult patients

AD is associated with several comorbidities, both allergic and non-allergic, indicating its systemic nature, particularly bacterial and fungal infections, neuropsychiatric disorders, autoimmune diseases, metabolic diseases and haematologic malignancies (914)

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Results Inhibition of glutathione metabolism depletes neuronal glutamate and affects excitatory transmission To test the hypothesis that glutathione is a significant reservoir for glutamate, we treated neuronal cells with molecular inhibitors targeting enzymes of the glutathione metabolic cycle: L-2-imidazolidone-4-carboxylate (2I4C), acivicin, L-buthionine sulfoximine (BSO), and sulforaphane

Further, an increase in left atrial myocardial capillary density (1.6-fold) and phosphorylation of eNOS (twofold) was also noted