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brown adipose tissue: 300 g)

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PTPs regulate signal transduction pathways involving tyrosine phosphorylation and have been implicated in the development of cancer (84, 85)

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For example, GLP-1RAs can target invariant natural killer T (iNKT) cells and consequently reduce the production of proinflammatory cytokines such as IFN-, IL-2, IL-4, IL-10, IL-17, TNF-, and GM-CSF and possibly increase the production of anti-inflammatory cytokines such as IL-10

In this catalytic cycle, a significant amount of reactive oxygen species (ROS) is produced, inducing an oxidative stress (Cederbaum, 2010