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[PMC free article: PMC2690426] [PubMed: 19293261] 67

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In RA, synovial stromalimmune cell interactions lead to reciprocal metabolic changes that potentiate the inflammatory response

In addition, altered metabolite concentrations after glucose administration also influence multiple metabolic pathways including glycolysis, gluconeogenesis, glycogenesis, amino acid metabolism, and lipid metabolism by regulating the abundance of substrates and products and the allosteric regulation of metabolic enzymes 14,16,17,18

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