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In the STEP 4 trial, people who continued semaglutide lost a further 7.9% over the next 48 weeks, while those who switched to a placebo injection regained 6.9%

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Notably, recent research suggests this relationship is bi-directional: aging causes circadian/sleep disruption, and conversely, circadian disruption can accelerate aspects of aging ( Given these insights, there is intense interest in identifying interventions that can stabilize or strengthen circadian rhythms in older people

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