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In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47

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Inhibition of protein synthesis rescues both mTORC1 signaling and the ISR during cystine starvation Protein synthesis takes precedence over other cysteine-consuming pathways under normal and particularly under sulfur-deficient conditions 22

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