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This path avoids stomach acid and first-pass liver metabolism, often leading to much higher and faster bioavailability than standard capsules
While you may think that the obvious solution to this problem is selenium supplementation, doing this has been shown to cause numerous gut issues, as well as other adverse effects
The brain regions studied include the frontal cortex, midfrontal cortex, inferior frontal gyrus, hippocampus, subiculum, entorhinal cortex, amygdala, temporal cortex, inferior temporal cortex, visual cortex, parietal cortex, putamen, caudate, middle and superior frontal gyri, middle temporal gyrus, white matter, grey matter, and subcortical regions
doi: 10.1042/bj0430193
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