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Most importantly, arrive with realistic expectations

PMID 33595889

This was supported in a post hoc analysis of SAVOR TIMI 53 participants showing that exposure to metformin did not significantly affect cardiovascular outcomes in patients with to severe CKD (19)

Unlike trial populations, this real-world population allowed us to estimate the cost-effectiveness of SGLT2is and GLP-1 RAs among the entire population with type 2 diabetes

doi: 10.1016/j.bbr.2010.05.033 43 VakalopoulosC