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Limited data exists for: Understudied Populations: Adults over 75 years (increased sensitivity to appetite suppression) Adolescents (ongoing development considerations) Individuals with BMI under 27 (insufficient safety data) Pregnant or lactating individuals (no safety data) Individuals with significant psychiatric conditions Gender Considerations: Research suggests some metabolic peptides may show differential effects between males and females, though data for cagrilintide and retatrutide specifically remains limited

This mechanism is different from acid-suppressing drugs like proton pump inhibitors (PPIs) or H2 blockers, which reduce acid production but do not affect the LES function directly

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Anyone experiencing fatigue, low energy, brain fog, or known B12 deficiency may benefit

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