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After this point, hepatocytes (liver cells) are unable to keep up

Additionally, if you take GLP-1 medications alongside insulin or sulfonylureas, monitor for signs of hypoglycaemia (low blood sugar) when reducing your food intake, as you may need medication adjustments

reported that GLP-1RA alleviated endoplasmic reticulum oxidative stress and hepatic steatosis in mice even without weight loss [48]

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They have not undergone the rigorous pre-market review process that FDA-approved medications complete