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Berberine has shown promise in some trials for improving glycaemic control in type 2 diabetes, with mechanisms possibly involving improved insulin sensitivity and altered gut microbiota

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The standard dosing regimens have been established through extensive pharmacokinetic and pharmacodynamic studies, ensuring that therapeutic drug levels are achieved and maintained

doi: 10.1016/j.amjmed.2009.11.019 54 RosenstockJKlaffLJSchwartzSNorthrupJHolcombeJHWilhelmKet al