Despite the great effects of these drugs in controlling hyperthyroidism, their administration is associated with hepatotoxicity as a serious side effect.8,9 Hepatic injury induced by these agents could be so severe that might lead to hepatic failure and requirement for liver transplantation,10,11,12 and even death has been reported in some cases.13,14 Liver transaminase abnormality, that might indicate subclinical liver injury, is a common event after PTU administration.12,15 Kim et al
Lancet Oncol 13(12):12251233 Yang Y et al (2016) Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Note that neither BPC-157 or TB-500 are approved for compounding, though both are up for debate at the advisory council meeting
GLP-1 receptor agonists may reduce inflammation through direct mechanisms (modulating immune cell function, reducing oxidative stress) and indirect effects from weight loss and improved metabolic control
Highly processed foods, fried foods, and refined seed oils generate advanced glycation end products and lipid peroxides that demand glutathione for cleanup
Moreover, GSH can protect cell death against ferroptosis, a non-apoptotic-regulated cell death culminating with overwhelming lipid peroxidation (6567)
