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Semaglutide influences this system by binding to GLP-1 receptors in areas of the brain involved in hunger and fullness cues

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10.1016/j.phymed.2022.153942 32 GuoM.WangZ.DaiJ.FanH.YuanN.GaoL.et al (2023)

A personalized genetic assessment may reveal whether you have genetic predispositions that favor GLP-1 monotherapy, alternative mechanisms, or heightened sensitivity to sympathomimetic effects

While coffee can have some benefits for your health, its not for everyoneand moderation is key