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Persistent mitochondrial OXPHOS in CRC cells enables metabolic compensation that undermines EMP-targeted therapies, necessitating combinatorial inhibition of complementary pathways (e.g., TCA cycle, PPP) for durable efficacy

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Serum levels of IS and p-CS were significantly lowered, and data obtained indicated that the Lm-low dose group (10 7 CFUs) demonstrated greater efficacy in mitigating CKD progression and restoring the gut microbiota balance as against the Lm-high dose group (10 9 CFUs) (Huang et al., 2021)