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In laboratory studies, Retatrutide is investigated for its potential to modulate biological signaling through simultaneous engagement of three receptor pathways: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

The separation provides clearer attribution if any unexpected effects occur

Other patients may experience optic ischemia (low blood supply to the eye) or optic neuritis (inflammation of the optic nerve)

doi: 10.1016/S0016-5085(24)01827-4 101 LevineISekhriSSchreiber-StainthorpWLockeBDelauOElhawaryMet al