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They likely reflect the difference between pathological IGF-1 excess (which does appear to increase cancer risk and accelerate ageing in some models) and normalisation of IGF-1 in individuals whose levels have declined below an optimal physiological range due to somatopause

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Ipamorelin Side Effects Considering the sparse human trial data available, few side effects have been observed in subjects undergoing ipamorelin administration, and no long-term side effects have been established